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12.02.2010: Phospholipase A2 inhibition

Phospholipase A₂ inhibition

By local administration of strontium, together with dermal penetration enhancers, the strontium concentrations in tissue close to the skin can be sharply elevated.

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It is known that strontium can interfere with calcium dependant phospholipase A₂ enzymes where it act as an antagonist. Through such inhibition strontium will reduce production of arachidonic acid, thereby inhibit the formation of the bioactive arachidonic acid metabolites that are involved in inflammation and pain processes.

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Nerve cell

A nerve cell or neuron is an electrically excitable cell that processes and transmits information by electrochemical signalling. All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium.

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